If You Go ...
Mesa is really a suburb of Phoenix, and as such you'll probably be spending a good chunk of your time there. Architecture fans will want to check out Taliesin West, conveniently located on Frank Lloyd Wright Drive in nearly Scottsdale. Frank Lloyd Wright and the Taliesin Fellowship wintered at Taliesin West, and today that unique set of buildings set amongst 600 acres of desert is open for tours.
Otherwise, the pickins are slim in terms of must-see attractions in Phoenix. You may want to do what the natives seem to enjoy: relax and commune with nature. Of course, most of that communing takes place on a golf course.
There are 11 other teams with spring-training venues in the Phoenix area: San Diego Padres (Peoria), Seattle Mariners (Peoria), Milwaukee Brewers (Maryvale), Oakland Athletics (Phoenix), Los Angeles Angels of Anaheim (Tempe), San Francisco Giants (Scottsdale), Cleveland Indians (Goodyear), Los Angeles Dodgers (Glendale), Chicago White Sox (Glendale0 Texas Rangers (Surprise) and Kansas City Royals (Surprise). Tucson -- spring-training home of the Arizona Diamondbacks and Colorado Rockies -- is 115 miles southwest of Phoenix. It's not really a bad drive -- it's mostly freeway, along I-10.
Where to Stay: Because there are so many spring-training venues in Phoenix and you're more than likely visiting more than one ballpark, chances are pretty good that you don't necessarily need to be staying close to the ballpark. Phoenix is a relatively easy area to make your way around, so don't feel like it's essential you stay close to the park. For what it's worth, the Cubs stay at Best Western Dobson Ranch Inn and Resort during spring training.
If you do feel compelled to stay close to the ballpark, there are several hotels within two miles of HoHoKam Park, including the Best Western Mezona, Phoenix Marriott Mesa Hotel & Convention Center, Holiday Inn Mesa, Ramada Inn Mesa, and the Quality Inn. But remember: no one in Phoenix walks anywhere. They drive.
Flying In: The closest airport is Phoenix Sky Harbor International Airport. It's served by all the major airlines, including United, America West, Delta, Air Canada, American, Continental, US Airways, and Southwest. It's a pleasant enough airport.